Justin Herbert concluded his excellent rookie season with his third four-touchdown game, and the pieces are in place for the Chargers offense to reach another level in 2021.
Jared Goff suffered a broken thumb during Sunday's loss to Seattle, leaving his Week 17 status in question with John Wolford as the on-call replacement.
Clyde Edwards-Helaire's return to Louisiana cruelly concluded with a somewhat concerning hip injury, while Jalen Hurts impressed again in his second start.
The Raiders defense can make a lot of players look good, but Jonathan Taylor's breakout game Sunday was a welcome one all the same.
Just when it seemed like he couldn't fall any further, Carson Wentz found himself on the bench and Jalen Hurts in to replace him late in Sunday's loss to Green Bay.
Austin Ekeler returned to the field against the Bills after a seven-game absence and immediately took up a starring role in the Justin Herbert offense.
A torn ACL on Sunday ended what was otherwise a promising and productive rookie year for Joe Burrow, who finishes 2020 with 16 touchdowns (three rushing) in just under 10 games.
The Saints got their victory, but a ribs injury to Drew Brees has their short-term quarterback situation up in the air for now.
It didn't take long Sunday for Christian McCaffrey to settle any concerns about his ankle, but he picked up a new rib concern before the game's conclusion.
Dalvin Cook had one of the best fantasy football box scores of recent memory Sunday, scoring four touchdowns and leading the Vikings to a road upset over Green Bay.
Aaron Rodgers needed a strong Week 7 bounce back after imploding against the Buccaneers in Week 6, and a four-touchdown showing against Houston should suffice.
Peak Derrick Henry normally shows up in November, but his 212 yards rushing in Week 6 may have heralded an early arrival in 2020.
Dak Prescott cruelly suffered a season-ending ankle injury against the Giants, casting a cloud over a day that was somewhat eventful otherwise.
In a day with several discouraging injuries, a knee injury to Nick Chubb may prove the headliner, pending MRI results.
With a five-touchdown showing in a high-stakes win against a good defense Sunday, Josh Allen appears to have turned a corner in his quarterback development.
In a day full of frustrating injuries, a suspected season-ending torn ACL suffered by Saquon Barkley stands out as especially painful.
It's been a while, but Aaron Rodgers looked like the genuine article in his dominant Week 1 effort against the Vikings on Sunday.
Derrick Henry ran for 211 yards and three touchdowns against Houston on Sunday, earning him the league rushing title in what's now one of the league's most crowded skill position offenses.
It was a costly home loss for the Seahawks on Sunday, as their recent loss of Rashaad Penny (ACL) was compounded by season-ending injuries to Chris Carson (hip) and C.J. Prosise (arm).
Julio Jones went berserk against the 49ers on Sunday, posting 134 of Atlanta's 210 receiving yards and scoring twice, including a last-second game winner in the 29-22 upset.
Austin Ekeler posted one of the most explosive and efficient box scores of recent memory against Jacksonville, totaling 213 yards and two touchdowns from scrimmage on just 12 touches.
The Dolphins managed the upset of the tailspinning Eagles, thanks primarily to the ongoing breakout campaign of DeVante Parker.
Chris Carson fumbled against Philadelphia in a game where Rashaad Penny went over triple-digit rushing yardage, bringing the former first-round pick back onto the fantasy radar.
Even with Amari Cooper in and out of the game due to injury, Dak Prescott gained in the MVP race by throwing for 444 yards and three touchdowns in a 35-27 victory over Detroit.
A late Kyler Murray interception undid the work of a three-touchdown connection with Christian Kirk, but the Arizona passing game appears to be on its way to an impressive product.
Lamar kept rolling against the Patriots, taking down what had been the NFL's best defense. He's on pace for 3,600 yards and 24 touchdowns passing to go with nearly 1,300 yards and 10 touchdowns rushing.
Jared Goff had another strong fantasy showing Sunday, but he's completed just 57.4 percent of his passes the last two weeks and hasn't completed 60 percent in a game in a month.
Aaron Rodgers had only eight touchdowns in his first six games but lit up the Raiders for six touchdowns Sunday, perhaps righting the ship.
Sam Darnold showed no rust following a difficult Week 1 and then a bout with mono, throwing for 338 yards and two touchdowns in the Jets' upset of Dallas.
Kyler Murray took his rushing production to a new height on Sunday, a good sign for him and the Arizona offense in general as it tries to move the chains more consistently.